Unlockable weapons
| Weapon | Requirements |
| Great caliber machine gun (only Chris) | Up to the maximum the level of the VZ61 machine gun. |
| Hydra three -channel shotgun | The Ithaca m93 shotgun level rises to the maximum. |
| Ballesta (only Sheva) | The maximum rise of the S75 rifle. |
| M93R pistol (customized by Samurai Edge) | The M92F gun level rises to the maximum. |
| S&W M500 (handcap) | The Magnum S&W M29 level rises to the maximum. |
Items regeneration
In the chapter twenty-one , Get all the items and then leave the game. Go back to the game by selecting Continue And you will start chapter 2 – 1 with the same items with which you left the game. However, the items you collected at the beginning are there again, so you can get them again. Repeat the same as long as you want. The same also happens in the chapter 3 – 1 .
LANZA-COHETES INFINITO
To unlock the spear-coheretes with infinite ammunition, complete the game in less than five hours in any difficulty. Then, activates infinite ammunition in the extra zone.
DLC trophies
| Trophies | Requirements |
| Bronze | |
| Army of One | Win 30 games in Slayers mode. |
| Eye of the Tiger | Win 30 games in Survivors mode. |
| It takes two to tango | Change 40 losses in Team Slayers. |
| It’s all about the points | Get at least 40.000 points in Survivors. |
| Keep The Good Times Rolling | Change 20 losses in Team Slayers. |
| Let’s get This Party Started! | Unlock all the selectable characters in versus. |
| There’s no “i” in team | Get at least 80.000 points in Survivors. |
| Silver | |
| Bringing the Pain | Expires one hundred players with melee attacks in versus mode. |
| The Team That Slays Together… | Win 30 games in Team Slayers. |
| We Will Survive | Win 30 games in Team Survivors. |
Unlockable mercenary characters
| Character | Requirements |
| Chris (Safari) | Get score to or higher in The Village. |
| Chris (Stars) | Get score to or higher in Experiment Facility. |
| Jill (Battle Suit) | Get score to or higher in Ship Deck. |
| Jill (BSAA) | Get score to or higher in Public Assembly. |
| Sheva (Clubin) | Get score to or higher in ancient ruins. |
| Sheva (Tribal) | Get score to or higher in Missile Area. |
| Wesker (Midnight) | Get score to or higher in The Mines. |
| Wesker (Stars) | Get or higher score in The Prison. |
Bonuses when completing the game
| Unlockable | Requirements |
| Alternative suit | Complete the game once. |
| Horror classic filter | Complete the game in amateur difficulty. |
| Resident Evil History | Complete the game once. |
| Infinite ammo | Complete the game once. |
| Mercenaries | Complete the game once. |
| New game+ | Complete the game once. |
| Noise filter | Complete the game in veteran difficulty. |
| Play as Sheva | Complete the game once. |
| Professional mode | Complete the game in veteran difficulty. |
| Retro filter | Complete the game in normal difficulty. |
Videguía Lost in Nightmares
Episode Guide Extra Lost in Nightmares.
Tips the mercenaries
A series of tips to obtain the best score in the mercenaries mode.
| Trophies | Requirements |
| Bronze | |
| To Cut Above | Defeat five enemies with the knife. |
| A FRIEND IN NEED | Save your companion ten times when you see the aid sign. |
| Bad Blood | Inflicate a lot of damage to your worst enemy. |
| Baptism of Fire | Defeat three majini at the same time with an explosion of a gas or drum tank. |
| Bull’S-Eye | Expires 30 enemies with the crossbow. |
| Cattle Prod | Expires 30 enemies with the bug bar. |
| Completed Chapter 1 – 1 | Complete chapter 1 – 1 at any difficulty level. |
| Completed Chapter 1 – 2 | Complete chapter 1 – 2 at any difficulty level. |
| Completed Chapter 2 – 1 | Complete chapter 2 – 1 at any difficulty level. |
| Completed Chapter 2 – 2 | Complete chapter 2 – 2 at any level of difficulty. |
| Completed Chapter 2 – 3 | Complete chapter 2 – 3 at any difficulty level. |
| Completed Chapter 3 – 1 | Complete chapter 3 – 1 at any difficulty level. |
| Completed Chapter 3 – 2 | Complete chapter 3 – 2 at any difficulty level. |
| Completed Chapter 3 – 3 | Complete chapter 3 – 3 at any difficulty level. |
| Completed Chapter 4 – 1 | Complete chapter 4 – 1 at any difficulty level. |
| Completed Chapter 4 – 2 | Complete chapter 4 – 2 at any level of difficulty. |
| Completed Chapter 5 – 1 | Complete chapter 5 – 1 at any level of difficulty. |
| Completed Chapter 5 – 2 | Complete chapter 5 – 2 at any level of difficulty. |
| Completed Chapter 5 – 3 | Complete Chapter 5 – 3 at any difficulty level. |
| Completed Chapter 6 – 1 | Complete chapter 6 – 1 at any difficulty level. |
| Completed Chapter 6 – 2 | Complete chapter 6 – 2 at any level of difficulty. |
| Completed Chapter 6 – 3 | Complete chapter 6 – 3 at any level of difficulty. |
| Crowd Control | Expires 30 enemies with the machine gun. |
| Egg Hunt | Find the four types of eggs. |
| Egg on your face | Win a majini with a rotten egg. |
| Exploding Heads | Make 20 shots at the head. |
| Fireworks | Shoot a molotov cocktail, dynamite cartridge or enemy grenade. |
| Get Physical | Expires 20 enemies with melee attacks. |
| Go into the light | Expires two enemies with a grenade. |
| Heart Stopper | Expires an enemy in particular stabbing him in his heart. |
| Lifeguard | Save your company ten times when you see the sign that he is dying. |
| Masters of Remaving | Work together to save someone very special. |
| Meat Shower | Expires 3 Majini with a granada or a proximity bomb. |
| Recruit | Complete all chapters in amateur mode. |
| Ride The Lightning | Expires a majini using the electric current of a transformer. |
| Soldier | Complete all chapters in normal mode. |
| Stop, Drop, & Roll | Expires three majini at the same time burning oil boats. |
| The Works | Chained the maximum number of combos at once. |
| Silver | |
| All Dressed Up | Buy all alternative costumes in the Bonus features section. |
| Badge of Honor | Find all Bsaa emblems. |
| Be the Knife | Reject an arrow with the knife. |
| Drive by | For a battleship truck killing the driver. |
| Lead Aspirin | Win a majini with a shot in the head while jumping. |
| Stockpile | Get all the available weapons. |
| Take it to the max | The level of all weapons rises to the maximum. |
| They Belong in a museum | Get all the treasures of the game. |
| They’re action figures! | Collect all figures. |
| They veterate | Complete all chapters in veteran mode. |
| WHO DO YOU Trust? | Get a certain level of trust with your company. |
| Gold | |
| War Hero | Complete all chapters in maximum difficulty. |
| Platinum | |
| Resident Evil 5 Platinum Trophy 5 | congratulations! You have overcome all your fears in Resident Evil 5. |